Arizona Cardinals (5-7) vs. San Francisco 49ers (10-2)
The Cardinals lost 23-7 in San Francisco just three weeks ago, but, they have won four of their last five games. The Cardinals will be starting Kevin Kolb at QB instead of John Skelton this time around against the Niners, so I expect a much different football game. The 49ers dumped the hapless Rams in San Francisco last weekend, 26-0. Here is a look at the matchups in this game:
When the Cardinals have the ball: Beanie Wells is a little gimpy right now and the 49ers are only giving up 71.8 yards rushing per game and 3.3 yards per carry so far this year, so look for the Cardinals to be very pass heavy this weekend. The Niners will likely attempt to double cover Larry Fitzgerald, but that isn’t going to stop QB Kevin Kolb from throwing the ball to him. WRs Andre Roberts and Early Doucet are also going to be used a lot in this game for the Cardinals.
When the 49ers have the ball: The Niners are going to try to run the ball a lot in this game. In the first game between these two teams, the Niners ran the ball 42 times. The Cardinals are going to have to focus on stopping RBs Frank Gore and Kendall Hunter in an attempt to make the Niners one dimensional on offense. Alex Smith is having a solid year, so the Cardinals are going to try to get after him and try to force him into making some big mistakes. The Niners will likely continue throwing the ball down the field to WRs Kyle Williams, Michael Crabtree and Ted Ginn. The Cardinals will also have to worry about TEs Vernon Davis and Delanie Walker.
PREDICTION: 49ERS 23, CARDINALS 20

